David Sinclair has made aging research scientifically respectable. His work on sirtuins and NAD+ identified specific molecular pathways involved in aging, opening doors for targeted interventions. Sinclair's "Information Theory of Aging" proposes that aging results from loss of epigenetic information rather than accumulating damage. His lab demonstrated that epigenetic reprogramming can reverse cellular aging in mice. Beyond research, Sinclair has been effective at communicating longevity science to broader audiences through his book "Lifespan" and podcast. He practices what he preaches, publicly discussing his own supplementation and lifestyle protocols. Sinclair represents the bridge between academic longevity research and practical life extension.
Key contributions
- Discovered role of sirtuins and NAD+ in aging
- Developed the Information Theory of Aging
- Demonstrated epigenetic reprogramming can reverse aging in mice
- Author of "Lifespan: Why We Age and Why We Don't Have To"
Quotes (1)
“Aging is a disease, and that disease is treatable.”
Lifespan · 2019